While deploying MS Exchange 2013 I experienced issues with accessing the Exchange Management Shell and Exchange Toolbox. Whenever I tried to open the Exchange Management Shell I kept get the following error:

VERBOSE: Connecting to Exchange2013.DOMAIN.LOCAL
New-PSSession : [exchange2013.domain.local] Connecting to remote server exchange2013.domain.local failed with the following error message : The WinRM client cannot process the request. The WinRM client tried to use Kerberos authentication mechanism, but the destination computer (exchange2013.domain.local) returned an 'access denied' error. Change the configuration to allow Kerberos authentication mechanism to be used or specify one of the authentication mechanisms supported by the server. To use Kerberos, specify the local computer name as the remote destination. Also verify that the client computer and the destination computer are joined to a domain. To use Basic, specify the local computer name as the remote destination, specify Basic authentication and provide user name and password. Possible authentication mechanisms reported by server: For more information, see the about_Remote_Troubleshooting Help topic.

VERBOSE: Connecting to EXCHANGE2013.LOCAL.COM.
New-PSSession : [exchange2013.domain.local:80] Connecting to remote server exchange-bt.tmal.com failed with the following error message : The WinRM client cannot process the request. The WinRM client tried to use Kerberos authentication mechanism, but the destination computer (exchange2013.local.COM:80) returned an 'access denied' error. Change the configuration to allow Kerberos authentication mechanism to be used or specify one of the authentication mechanisms supported by the server. To use Kerberos, specify the local computer name as the remote destination. Also verify that the client computer and the destination computer are joined to a domain. To use Basic, specify the local computer name as the remote destination, specify Basic authentication and provide user name and password. Possible authentication mechanisms reported by server: For more information, see the about_Remote_Troubleshooting Help topic.

Workaround and Resolution:

Searching the error on Google and all over the web resulted in various and numerous solutions most that worked for there environment but failed to address my issue, but made me realize that this was a Powershell website issue. 
Exchange 2013 installs a Default Website (Client Access front End) on port 80 and 443 and also a Backend Website on port 81 and 444.

Here is how i managed to sort out my issue, I had to Change the physical path from: C:\Program Files\Microsoft\Exchange Server\V15\FrontEnd\HttpProxy\PowerShell to: C:\Program Files\Microsoft\Exchange Server\V15\ClientAccess\PowerShell and then issued an IISRESET.

This is how I went about diagnosing this, with the first Exchange Server 2013 installed and running, I installed a second Exchange 2013 Server with only the Mailbox server role.
On the second Exchange Mailbox server I was able to access the EMS and the Exchange Toolbox successfully.
Now from here on it's simple I only have to do a comparison of the Powershell settings in IIS Manager on these two Exchange servers.

Internet Information Services (IIS) Manager, Sites, Default Web Site, PowerShell and in the Actions Pane, choose Basic setting, physical Paths - on exchSvr1 has C:\Program Files\Microsoft\Exchange Server\V15\FrontEnd\HttpProxy\PowerShell while exchSvr2 has C:\Program Files\Microsoft\Exchange Server\V15\ClientAccess\PowerShell on exchSvr1 changed the physical path to C:\Program Files\Microsoft\Exchange Server\V15\ClientAccess\PowerShell

After changing all these i did an iisrest on the exchSvr1 (the affected server) and tried the EMS and Exchange Toolbox, they all worked.

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