PyQt5--GridLayout

 # -*- coding:utf-8 -*-
 '''
 Created on Sep 13, 2018

 @author: SaShuangYiBing
 '''
 import sys
 from PyQt5.QtWidgets import QApplication,QWidget,QPushButton,QGridLayout

 class New_test(QWidget):
     def __init__(self):
         super().__init__()
         self.initUI()

     def initUI(self):
         grid = QGridLayout()
         self.setLayout(grid)

         names = ['Cls','Bck','','Close','','','','/','','','','*','','','','-','','.','=','+']

         positions = [(i,j) for i in range(5) for j in range(4)]

         print (list(zip(positions,names)))

         for position,name in zip(positions,names):
             if name == '':
                 continue
             button = QPushButton(name)
             grid.addWidget(button,*position)

         self.move(300,150)
         self.setWindowTitle('Calculator')
         self.show()

 if __name__ == "__main__":
     app = QApplication(sys.argv)
     ex = New_test()
     sys.exit(app.exec_())