Dissecting evolution and disease using comparative vertebrate genomics-online 因为基因组不是独一无二的,同时人类基因组可以组为参考数据,所以最近这些年涌现了脊椎动物的基因数据,所以我们可以利用比较基因组学获得生物学各方面的内在机制,以此来预测和调节疾病. 两种方式获得人类基因组:方式一:多级策略:(IHGSC)工程量巨大(因为工程量巨大,所以急需的测序技术(新且造价低)),使用了BAC克隆同时高coverage(准确率…
Falcon Falcon: a set of tools for fast aligning long reads for consensus and assembly The Falcon tool kit is a set of simple code collection which I use for studying efficient assembly algorithm for haploid and diploid genomes. It has some back-end c…
http://gmod.org/wiki/MAKER_Tutorial 简单好用 identify repeats, to align ESTs and proteins to the genome, and to automatically synthesize these data into feature-rich gene annotations, including alternative splicing and UTRs, as well as attributes such as…
准备读四篇denovo的文献: Nature Biotechnology(2015) - Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutio…
Evolutionary approaches towards AI: past, present, and future 2019-10-06 07:28:13 This blog is from: https://towardsdatascience.com/evolutionary-approaches-towards-ai-past-present-and-future-b23ccb424e98 Table of Contents Introduction Genetics and na…
(Panda, dog and human repeat comparison):与其他动物比较重复序列 我们使用Repbase 库(重复序列库)+已知的转录原件序列+识别软件,评估出转录原件占比,并且与狗和人相比.用Repbase数据库(扩张度来自repeat base)分析熊猫基因中的转录原件的扩张度,得到:大部分熊猫转录原件基因有超过10% 的共有序列的扩张度(这是因为repbase数据库数据基于哺乳动物基因,并没有大熊猫基因).小部分低于10%的扩张度(这可能是哺乳动物最近起源的活性转座…