文献名:Proteome Analysis of Human Neutrophil Granulocytes From Patients With Monogenic Disease Using Data-independent Acquisition(单基因疾病患者中性粒细胞的DIA蛋白质组分析) 期刊名:Mol Cell Proteomics 发表时间: (2019年4月) IF:5.232 单位: 德国柏林工业大学生物技术研究所 德国慕尼黑 Dr.vonHauner儿童医院 物种:人类中性…

文献名:Systematic comparison of strategies for the enrichment of lysosomes by data independent acquisition(通过DIA技术系统比较各溶酶体富集策略) 期刊名:Journal of Proteome Research 发表时间:(2020年1月) IF:4.268 单位: 德国波恩大学 瑞士Biognosys公司 物种:HEK293细胞 技术:数据非依赖性采集(DIA)   一. 概述: 本研究基于…

目录 1. 简介 2. 近几年发表的主要工具 1.DeepRT 2.Prosit 3. DIANN 4.DeepDIA 1. 简介 基于串联质谱的蛋白质组学大部分是依赖于数据库(database search)的bottom-up策略研究.也就是实际谱图和理论谱图进行匹配打分,从而实现肽段和蛋白的鉴定和定量.如果是DDA的数据,因为一张二级谱是一条肽段,直接将数据库理论酶切碎裂后的理论谱和实际谱图匹配即可.但如果是DIA的数据,因为二级谱是混合谱,即来源于很多肽段,而且碎片离子还会受到未碎裂的母…

前言 关于蛋白质组学,你是不是已经听了太多公司的宣讲,介绍了一大堆的技术名词,反而越听越懵懂,脑袋一团乱麻?就和传话游戏一样,当我们接收了多手信息以后,得到的信息就越不准确.那么,何不自己看一看第一手信息呢?比如说DIA. 这里只推荐两篇综述. 第一篇是蛋白质组学泰山北斗的Ruedi Aebersold和Matthlas Mann合作发的,该文不止介绍DIA,是对整个目前蛋白质组的bottom-up得研究策略做的一个总结和展望. 整个bottom-up的蛋白质组学研究流程如下图所示: 第二篇也是…

文献名:Current understanding of human metaproteome association and modulation(人类宏蛋白质组研究近期综述) 期刊名:J Proteome Res 发表时间: (2019年10月) IF:3.78 技术:宏蛋白质组综述   一. 概述:(用精炼的语言描述文章的整体思路及结果) 过去的十年中,宏蛋白为人们更好地了解微生物组的功能特征提供数据.尽管已经有高通量宏蛋白质组的数据,但是对其功能的认识还不清楚,最重要的是,这些蛋白质分子…

期刊名:Journal of Proteome Research 发表时间:(2019年9月) IF:3.78 单位: 中国科学院大连化学物理研究所 中国科学院大学 大连医科大学第二附属医院 物种:人血浆 技术:用组氨酸修饰的具有可变换表面电荷的亲水性智能材料(组氨酸键合的二氧化硅,HBS)可选择性地从复杂的生物样品中富集唾液酸化的糖肽(SGP)   一. 概述: 糖蛋白的异常唾液酸化与许多恶性疾病密切相关,唾液酸化的分析对于揭示这些疾病的现状具有很大的潜力.然而,深入分析唾液酸化仍然具有挑战性…

文献名:Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints Secreted Proteins for Vaccine Development(从人类血吸虫曼氏血吸虫中富集的食道和肠道组织的定量蛋白质组学确定了用于疫苗开发的分泌蛋白) 期刊名:Journal of Proteome Research 发表时间:…

文献名:Proteomic and N-Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification(人类牙槽骨蛋白的蛋白质组学和n端分析:改进的蛋白质提取方法和Ly…

Title: Single-Shot Capillary Zone Electrophoresis−Tandem Mass Spectrometry Produces over 4400 Phosphopeptide Identifications from a 220 ng Sample Journal: Journal of Proteome Research Published Date: June 10, 2019 DOI: 10.1021/acs.jproteome.9b00244 R…

In my last article, I stated that for practitioners (as opposed to theorists), the real prerequisite for machine learning is data analysis, not math. One of the main reasons for making this statement, is that data scientists spend an inordinate amoun…

Building the Unstructured Data Warehouse: Architecture, Analysis, and Design earn essential techniques from data warehouse legend Bill Inmon on how to build the reporting environment your business needs now! Answers for many valuable business questio…

版权声明:本文为博主原创文章,未经博主允许不得转载. https://blog.csdn.net/u010825142/article/details/15338085 聪明的人在出现问题的时候,除了解决问题外,都会想到如何避免问题以后再次发生,避免的办法可能是从过程或者技术两个方面入手,从根本杜绝问题的发生.问题分析是很常见的,为什么在5级的时候才有这样的要求呢?难道2.3级的企业,甚至是没有级别的企业,就不会做问题分析并防止问题再次发生吗? 5级的这个CAR没有这么简单的,如果要通过5级这个…

A data analysis system, particularly, a system capable of efficiently analyzing big data is provided. The data analysis system includes an analyst server, at least one data storage unit, a client terminal independent of the analyst server, and a cach…

文献名:A Systems-Level Characterization of the Differentiation of Human Embryonic Stem Cells into Mesenchymal Stem Cells(人类胚胎干细胞到间充质干细胞的分化的系统性表征) 期刊名:Molecular & Cellular Proteomics 发表时间:(2019年10月) 单位: Camargo Cancer Center University of Southern Denmar…

文献名:Quantifying Protein-Specific N-Glycome Profiles by Focused Protein and Immunoprecipitation Glycomics(聚焦和糖组学免疫沉淀法定量N-糖图谱) 期刊名:Journal of Proteome Research 发表时间:2019 Aug 2 DOI: 10.1021/acs.jproteome.9b00232 IF: 4.173 单位: 1.日本札幌北海道大学医学研究生院胃肠和肝病学系 2.…

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Computational Geometry The Geometry Center (UIUC) Computational Geometry Pages (UIUC) Geometry in Action (UIC) Geometric Resource (UFL) CAGD Applets (UKA) Voronoi/Delaunay Applet (CornellUniversity) Directory of Computational Geometry Software (Dr. N…

factoextra is an R package making easy to extract and visualize the output of exploratory multivariate data analyses, including: Principal Component Analysis (PCA), which is used to summarize the information contained in a continuous (i.e, quantitati…

有些词可能共用一些缩写.带星号的缩写或词来源于PeopleSoft标准. The following standard word abbreviations should be used in naming records, fields, and SQRs: Word(s) Abbreviation Description AbbreviateAbbreviation ABRV   Academic ACAD   AcceptAcceptanceAccepted ACPT   Access A…

Machine Learning Crash Course  |  Google Developers https://developers.google.com/machine-learning/crash-course/ Google's fast-paced, practical introduction to machine learning ML Concepts Introduction to Machine Learning As you'll discover, machine…

TCGA的关键数字:图片来源<细胞> 由美国政府发起的癌症和肿瘤基因图谱(Cancer Genome Atlas,TCGA)计划于2006年联合启动,目前已经收录了来自1万多例病人的33种癌症的数据,2.5PB的数据量.全世界无数顶尖肿瘤学家经过10多年的辛苦工作,于近期公布了TCGA研究的收官之作:“Pan-Cancer Atlas”泛癌症图谱.这些研究精华共发表了27篇相关论文,涉及基因组测序,转录组测序,甲基化等表观组学测序以及最终的整合分析,同时研究者也将它们与临床和影像数据相关联,展…

这么多工具和基因组版本,选择困难症犯了,到底用哪个好呢? 2018 nature - Developmental diversification of cortical inhibitory interneurons : ENSEMBL release 84 Mus musculus genome 2017 Molecular Cell - Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dyn…

  目录(?)[+]   1.搜狗实验室数据集: http://www.sogou.com/labs/dl/p.html 互联网图片库来自sogou图片搜索所索引的部分数据.其中收集了包括人物.动物.建筑.机械.风景.运动等类别,总数高达2,836,535张图片.对于每张图片,数据集中给出了图片的原图.缩略图.所在网页以及所在网页中的相关文本.200多G 2 http://www.imageclef.org/ IMAGECLEF致力于位图片相关领域提供一个基准(检索.分类.标注等等) Cross…

AIOps platforms enhance IT operations through greater insights by combining big data, machine learning and visualization. I&O leaders should initiate AIOps deployment to refine performance analysis today and augment to IT service management and autom…

1. Increasing resources on the critical path activities may not always shorten the length of the project with the following reasons or examples .which may bring the LEAST influence to resource increase ? A certain activities are time dependent rather…

1.EXEALL.m function EXEALL(FilePath, FileName)%执行所有流程% FilePath: 文件夹所在路径% FileName: 文件夹名称 FullPath = [FilePath , FileName , '\' , FileName , '.txt']; allPixelPath = [FilePath , FileName , '\', FileName , '.allpixel.csv']; TestdataPath = [FilePath , F…

一.改进模型的几个方法 Collect more data Collect more diverse training set Train algorithm longer with gradient descent Try Adam instead of gradient descent Try bigger network Try dropout Add \(L_2\) regularization Network architecture Activation functions hidd…

Reference: https://www.digitalocean.com/community/tutorials/how-to-install-and-configure-elasticsearch-on-ubuntu-14-04 Introduction Elasticsearch is a platform for distributed search and analysis of data in real time. Its popularity is due to its eas…

备注: 1.先要安装wheel库:pip install wheel 2.下载wheel,切换至下载路径,然后安装:pip install wheel库名.whl Windows Python Extension Packages by Christoph Gohlke, Laboratory for Fluorescence Dynamics, University of California, Irvine. HoloPy, a tool for working with digital h…

  MRIcro tutorial 参考网址:http://www.mccauslandcenter.sc.edu/mricro/mricron/ http://www.cabiatl.com/mricro/mricro/mricro.html This guide gives is a brief description of how you can use MRIcro and SPM to work with patient scans. For the MRIcro manual and…